INTRODUCTION:
The enzyme SGPT is widely reported in a variety of tissue sources. The major source of SGPT is of hepatic origin and has led to the application of SGPT determinations to the study of hepatic diseases. Elevated serum levels are found in hepatitis, cirrhosis, and obstructive jaundice. Levels of SGPT are only slightly elevated in patients following a myocardial infarction. UV methods for SGPT determination were first developed by Wroblewski and LaDue in 1956. The method was based on the oxidation of NADH by lactate dehydrogenase (LDH). In 1980, the International Federation of Clinical Chemistry (IFCC) recommended a reference procedure for the measurements of SGPT based on the Wroblewski and LaDue procedure. The SGPT reagent conforms to the formulation recommended by the IFCC.
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