INTRODUCTION:
Uric acid is the end product of purine metabolism. Nearly half of the total uric acid is eliminated and replaced each day by way of urinary excretion and through microbial degradation in the intestinal tract. Increased uric acid levels are commonly associated with both nitrogen retention and urea, creatine and other non-protein constituents. The quantitation of uric acid is an aid in the diagnosis of gout, decreased renal function, myeloproliferative disorders, and other conditions in which the cause for the hyper- uricemia is not well known. Uric acid is most commonly determined by a phosphotungstate method and iron reduction method. Due to serum interferences, the enzyme uricase has been widely used instead. Uricase is more specific for uric acid since uricase acts only on uric acid.
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